edinger lab

 
 

A resurgence of interest in cancer cell metabolism has led to the discovery that many oncogenes and tumor suppressor genes transform cells by altering cellular bioenergetics. While essential for oncogenesis, this metabolic reprogramming makes cancer cells exquisitely dependent upon a high rate of nutrient flux. This is a potential Achilles’ heel—constitutively-active oncogenes and the deletion of tumor suppressor genes prevent tumor cells from reducing biosynthesis and increasing catabolic reactions. Thus, cancer cells die when deprived of nutrients while normal cells become quiescent. My laboratory is taking a unique approach to fighting cancer by trying to exploit this difference by developing therapies that selectively starve cancer cells to death by down-regulating nutrient transporter proteins. Our immediate goal is to uncover the pathways that coordinately regulate mammalian nutrient transporter internalization and trafficking.

Starving Cancer Cells to Death

Lab Address:

Edinger Lab

Department of Cell & Developmental Biology

3302 Natural Sciences 1

University of California, Irvine

Mail Code: 2300

Irvine, CA 92697


Lab Phone: (949) 824-1035