2020 - 2016

Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines.

Bachollet SPJT, Vece V, McCracken AN, Finicle BT, Selwan E, Ben Romdhane N, Dahal A, Ramirez C, Edinger AL, Hanessian S.

ACS Med Chem Lett. 2020 Feb 12;11(5):686-690. doi: 10.1021/acsmedchemlett.9b00553. eCollection 2020 May 14. PMID: 32435371


Macropinocytosis confers resistance to therapies targeting cancer anabolism.

Jayashankar V, Edinger AL.

Nat Commun. 2020 Feb 28;11(1):1121. doi: 10.1038/s41467-020-14928-3. PMID: 32111826

Highlighted here: https://news.uci.edu/2020/03/03/starve-a-tumor-feed-a-cell-how-cancers-can-resist-drugs/


Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720.

Kemp JA, Keebaugh A, Edson JA, Chow D, Kleinman MT, Chew YC, McCracken AN, Edinger AL, Kwon YJ. Bioconjug Chem. 2020 Mar 18;31(3):673-684. doi: 10.1021/acs.bioconjchem.9b00822. Epub 2020 Jan 27.PMID: 31986014


Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A.

Garsi JB, Vece V, Sernissi L, Auger-Morin C, Hanessian S, McCracken AN, Selwan E, Ramirez C, Dahal A, Romdhane NB, Finicle BT, Edinger AL.

Bioorg Med Chem Lett. 2019 Sep 15;29(18):2681-2685. doi: 10.1016/j.bmcl.2019.07.023. Epub 2019 Jul 19.PMID: 31383588


Dynamic phosphoproteomics uncovers signaling pathways modulated by anti-neoplastic sphingolipid analogs.

Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault P.

Mol Cell Proteomics. 2018 Nov 27. pii: mcp.RA118.001053. doi: 10.1074/mcp.RA118.001053. PMID: 30482847


In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.

Garsi JB, Sernissi L, Vece V, Hanessian S, McCracken AN, Simitian G, Edinger AL.

Eur J Med Chem. 2018 Nov 5;159:217-242. doi: 10.1016/j.ejmech.2018.09.043. Epub 2018 Sep 21. PMID: 30292898


Starving PTEN-deficient prostate cancer cells thrive under nutrient stress by scavenging corpses for their supper.

Jayashankar V, Finicle BT, Edinger AL.

Mol Cell Oncol. 2018 Aug 17;5(4):e1472060. doi: 10.1080/23723556.2018.1472060. eCollection 2018. PMID: 30250923


Nutrient scavenging in cancer.

Finicle BT, Jayashankar V, Edinger AL.

Nat Rev Cancer. 2018 Oct;18(10):619-633. doi: 10.1038/s41568-018-0048-x. Review. PMID: 30097614


Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6.

Finicle BT, Ramirez MU, Liu G, Selwan EM, McCracken AN, Yu J, Joo Y, Nguyen J, Ou K, Roy SG, Mendoza VD, Corrales DV, Edinger AL.

J Cell Sci. 2018 Jun 25;131(12). pii: jcs213314. doi: 10.1242/jcs.213314. PMID: 29848659


PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells.

Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL.

Cancer Discov. 2018 Jul;8(7):866-883. doi: 10.1158/2159-8290.CD-17-1215. Epub 2018 Mar 23. PMID: 29572236


Highlighted in:

Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation.

McCracken AN, McMonigle RJ, Tessier J, Fransson R, Perryman MS, Chen B, Keebaugh A, Selwan E, Barr SA, Kim SM, Roy SG, Liu G, Fallegger D, Sernissi L, Brandt C, Moitessier N, Snider AJ, Clare S, Müschen M, Huwiler A, Kleinman MT, Hanessian S, Edinger AL.

Leukemia. 2017 Mar;31(3):669-677. doi: 10.1038/leu.2016.244. Epub 2016 Aug 30. PMID: 27573555

Branched chain amino acid metabolism and cancer: the importance of keeping things in context.

Selwan EM, Edinger AL.

Transl Cancer Res. 2017 May;6(Suppl 3):S578-S584. doi: 10.21037/tcr.2017.05.05. PMID: 30613481


Rab7-a novel redox target that modulates inflammatory pain processing.

Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A.

Pain. 2017 Jul;158(7):1354-1365. doi: 10.1097/j.pain.0000000000000920. PMID: 28394828


Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy.

Walker WP, Oehler A, Edinger AL, Wagner KU, Gunn TM.

Biol Cell. 2016 Nov;108(11):324-337. doi: 10.1111/boc.201600014. Epub 2016 Aug 23. PMID: 27406702


Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus.

Jaber N, Mohd-Naim N, Wang Z, DeLeon JL, Kim S, Zhong H, Sheshadri N, Dou Z, Edinger AL, Du G, Braga VM, Zong WX.

J Cell Sci. 2016 Dec 1;129(23):4424-4435. Epub 2016 Oct 28. PMID: 27793976


Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways.

Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL.

J Clin Invest. 2016 Nov 1;126(11):4088-4102. doi: 10.1172/JCI87148. Epub 2016 Sep 26. PMID: 27669461


JCI Author’s take: https://www.youtube.com/watch?v=Ny53-vBFLpY


Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death.

Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S.

Bioorg Med Chem. 2016 Sep 15;24(18):4390-4397. doi: 10.1016/j.bmc.2016.07.038. Epub 2016 Jul 18. PMID: 27475534


Age-related myelin degradation burdens the clearance function of microglia during aging.

Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M.

Nat Neurosci. 2016 Aug;19(8):995-8. doi: 10.1038/nn.4325. Epub 2016 Jun 13. PMID: 27294511


Highlighted in:

Attacking the supply wagons to starve cancer cells to death.

Selwan EM, Finicle BT, Kim SM, Edinger AL.

FEBS Lett. 2016 Apr;590(7):885-907. doi: 10.1002/1873-3468.12121. Epub 2016 Mar 22. Review. PMID: 26938658


Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky DJ, . . . , , Edinger AL, . . . , and Zughaier SM.

Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356. No abstract available. Erratum in: Autophagy. 2016;12(2):443. Selliez, Iban [corrected to Seiliez, Iban]. PMID: 26799652


Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.

Chen B, Roy SG, McMonigle RJ, Keebaugh A, McCracken AN, Selwan E, Fransson R, Fallegger D, Huwiler A, Kleinman MT, Edinger AL, Hanessian S.

ACS Chem Biol. 2016 Feb 19;11(2):409-14. doi: 10.1021/acschembio.5b00761. Epub 2015 Dec 14. PMID: 26653336

2015 - 2010
2009 - 2005
2004 - 1995